| abstract |
The present invention relates to hydroxy-tetrahydro-naphthalenyl urea derivatives and salts thereof useful as active ingredients in pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have excellent activity as VR1 antagonists and prevent and treat diseases associated with VR1 activity, particularly urinary incontinence, urge incontinence, overactive bladder, chronic pain, Useful for the treatment of neuropathic pain, postoperative pain, rheumatoid arthritis pain, neuralgia, neuropathy, hyperalgesia, nerve injury, ischemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD. |