| abstract |
The present invention relates to aryl or heteroaryl amide alkane derivatives of formula (I), wherein R 6 represents carboxy or tetrazolyl, useful as active ingredients in pharmaceutical formulations. The aryl or heteroaryl amide alkanes of the present invention have PGI2 antagonist activity and can be used for the prevention and treatment of diseases associated with PGI2 activity. Such diseases include urological diseases or disorders such as: subvesical obstruction, overactive bladder, urinary incontinence, detrusor hyperreflexia, detrusor instability, decreased bladder capacity, frequent urgency, urgency Urinary incontinence, stress urinary incontinence, bladder hyperresponsiveness, prostatic hypertrophy (BPH), prostatitis, frequent urination, nocturia, urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostate pain, cystitis or idiopathic Bladder hypersensitivity. The compounds of the present invention also include inflammatory pain, neuropathic pain, acute pain, chronic pain, tooth pain, premenstrual pain, visceral pain, headache and the like, pain; hypotension Also useful in the treatment of haemophilia and bleeding; and inflammation. Because these diseases are also related to PGI2. |