| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-811 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-563
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 |
| filingDate |
2003-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2006-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2006517198-A |
| titleOfInvention |
Diagnostic method of disease by screening hepcidin in human or animal tissue, blood or body fluid and therapeutic use therefor |
| abstract |
The present invention relates to methods and kits for diagnosing disease states characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; Contacting the sample with those antibodies or fragments thereof that specifically bind to a polypeptide corresponding to the central portion or C-terminus of the hepcidin protein, and hepcidin levels using an antibody and polypeptide binding based assay. A non-physiological level of hepcidin is indicative of the disease state. The present invention also relates to diagnostic methods and kits for use in genetic engineering approaches such as, for example, to overexpress or down regulate hepcidin. The invention further relates to the therapeutic treatment of certain diseases by treatment of subjects with hepcidin and hepcidin agonists or antagonists. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010539969-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9803011-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008146903-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323088-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9657098-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011502482-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012533582-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016027469-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010536364-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8614068-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8187827-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010517529-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016513664-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011519279-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008047485-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10239941-B2 |
| priorityDate |
2002-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |