abstract |
The present invention relates to novel peptides and compositions that can modulate viability and proliferation in neuronal cells, and methods of modulating neuronal viability and proliferation using the novel peptides and compositions of the present invention. In one aspect, the present invention relates to a novel peptide analog of motor neurotrophic factor 1 comprising either “WMLSAFS” or “FSRYAR domain” and sufficient for neuropathic or neurotrophic function. In particular, the present invention relates to a novel protein domain with general significance for the action of motor neurotrophic factors, which protein domain has been identified and two short partially overlapping sequences of the MNTF1 molecule Is mapped. |