| abstract |
Monovalent and multivalent scFv-antibodies containing binding sites specific for human T cell CD3 are described. These antibodies are highly immunosuppressive and do not cause significant release of cytokines. Furthermore, a polynucleotide encoding the antibody and a vector containing the polynucleotide, a host cell transformed thereby and their use in the production of the antibody are described. Pharmaceutical compositions containing any of the above polynucleotides, antibodies or vectors are useful for immunotherapy, preferably acute graft rejection. |