abstract |
The present invention relates generally to a group of polypeptides derived from mitochondrial membranes that bind to insulin-sensitizing antidiabetic thiazolozinediones, and nucleic acid sequences encoding the polypeptides. The present invention relates to methods for identifying therapeutic agents that bind to a polypeptide of the present invention. The invention further relates to methods useful for treating or modulating metabolic disorders in mammals in need of such biological effects. |