| abstract |
The present invention is a method for increasing the bioavailability of bisphosphonates, wherein an effective pre-dose vitamin D derivative, such as alpha calcidol or calcitriol, is administered and, after an interval time, a therapeutic dose A method comprising administering, for example, alendronate. The invention also relates to the use of vitamin D derivatives and bisphosphonates for the manufacture of a medicament for the treatment of osteoporosis, metastatic bone disease, Paget's disease and the like. |