| abstract |
Provided are compounds having Formula I, wherein the variables have the values described herein. A pharmaceutical formulation includes the compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, and combinations with other agents. A method of treating a patient includes administering a pharmaceutical formulation according to the present invention to a patient in need thereof. The present invention relates generally to the treatment of diseases (eg, cancer) characterized by abnormal activity of growth factors, protein serine / threonine kinases and phospholipid kinases. In other aspects, the present invention treats patients with small molecule inhibitors of phosphotidylinositol (PI) 3-kinase, pharmaceutical formulations containing such inhibitors, and using such pharmaceutical formulations Methods and methods for preparing such pharmaceutical formulations and inhibitors are provided. |