| abstract |
Antitumor compositions and methods for inhibiting the biological activity of PC cells derived from growth factors (PCDGF), anti-PCDGF receptor antibodies, and fragments thereof, and methods for producing PCDGF receptor antibodies. This method comprises inhibiting the growth of tumor cells expressing a PCDGF receptor by contacting the surface of the cell with a PCDGF receptor antibody. An anti-PCDGF receptor antibody can bind to the surface of a cell and interfere with anti-PCDGF receptor antibody binding to that receptor. Also provided are compositions comprising anti-PCDGF receptor antibodies and cytotoxic molecules (eg, toxins, oncotoxins, mitoxins, immunotoxins, and antisense oligonucleotides). The present invention also provides a method of diagnosing a tumorigenesis tendency by measuring the level of PCDGF in a tumorigenic tissue specimen or biological fluid. |