| abstract |
Disclosed are novel dihydropyridinone compounds of formula (I), wherein Ar, Ar ′ and R 1 are as defined herein, which are selective inhibitors of KDR and FGFR kinases. The These compounds and their pharmaceutically acceptable salts are useful anti-proliferative agents in the treatment or control of solid tumors, particularly breast cancer, colon cancer, lung cancer and prostate cancer. Disclosed are pharmaceutical compositions containing these compounds and their preparation. [Chemical 1] |