| abstract |
Conjugates of various biologically active ingredients with water-soluble polymers (eg poly (ethylene glycol) and derivatives thereof), in particular proteins, comprising methoxyl groups or other alkoxyl groups ( Methods are provided for preparing conjugates that have reduced antigenicity and immunogenicity compared to similar conjugates prepared using (ethylene glycol). The invention also provides conjugates prepared by these methods, compositions comprising the conjugates, kits comprising the conjugates or compositions, and uses of the conjugates and compositions in diagnostic and therapeutic planning. . |