abstract |
The present invention relates to compounds of formula (I), wherein rings A, X, Y, Z, R 1 , R 2 and R 3 are defined herein. These compounds are useful for the treatment and prevention of cancer, inflammatory disorders, autoimmune diseases and other conditions related to PDE4 or high levels of cytokines. The present invention also relates to pharmaceutical compositions containing at least one compound of formula (I) and methods for the treatment and prevention of cancer, inflammatory disorders, autoimmune diseases and other conditions related to PDE4 or high levels of cytokines. |