http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006509509-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00 |
| filingDate | 2003-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2006509509-A |
| titleOfInvention | Identification of genes involved in angiogenesis and development of angiogenic diagnostic chips to identify patients with angiogenesis disorders |
| abstract | The present invention is directed to a method for angiotyping an individual patient to predict the likelihood that an individual's collateral blood vessel development will be good or insufficient in nature. Thus, this can include obtaining and providing a list of genes involved in collateral vessel development. In particular, individual patient angiotyping can be used to predict the likelihood that an individual's collateral blood vessel development will be good or insufficient in response to a particular angiogenic therapy. From an array of genes that were determined to be differentially expressed in tissues that develop collateral vessels in response to arterial occlusion in experimental studies, other epigenetics such as single nucleotide polymorphisms (SNPs) or DNA methylation patterns Mutations can be identified. SNP or DNA methylation patterns are detected using microarrays or similar techniques that assay all or most of the genes determined to play a role in collateral blood vessel development. In addition, abnormally low or abnormally high differential expression of any combination of candidate genes can be detected in tissues such as peripheral blood cells. The presence of a predisposition to insufficient or good development of collateral vessels is indicated by the presence of SNPs or changes in DNA methylation patterns and / or differences in expression levels involved in one or more of these genes. |
| priorityDate | 2002-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.