| abstract |
The present invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) that specifically inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and / or aggrecanase activity. It is done. The present invention also provides MMP inhibition and / or aggrecanase inhibition efficacy to animals, particularly mammals having (or predisposed to) pathological conditions associated with MMP activity and / or aggrecanase activity. It is directed to a prophylactic or therapeutic method comprising administering in an amount. |