abstract |
Formula (I) useful for the treatment of COX-2-dependent diseases [Chemical 1] [Where, R is hydrogen, lower alkyl, (C 3 -C 6 ) cycloalkyl, hydroxy, halo, lower alkoxy, trifluoromethoxy, trifluoromethyl or cyano; and A is biaryl, optionally substituted β-naphthyl , Bicyclic heterocyclic aryl, (C 3 -C 6 ) cycloalkyl-monocyclic carbocyclic aryl, or (C 5 or C 6 ) cycloalkane fused-monocyclic carbocyclic aryl. ] And a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable ester thereof. |