| abstract |
Novel carbocyclic compounds of formula (I) Compositions and methods for inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and compositions and methods for treating GSK3-mediated injury in vivo are provided. The methods, compounds and compositions of the present invention can be used alone or in combination with other pharmaceutically active agents in treating disorders mediated by GSK3 activity. This treatment includes, for example, diabetes, Alzheimer's disease, other neurodegenerative disorders (eg Parkinson's disease and Huntington's disease), obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, X Treatment of syndrome, ischemia, traumatic brain injury, bipolar injury, immunodeficiency or cancer. |