| abstract |
To identify gene or group of gene modifications involved in Tourette syndrome (TS) and other related abnormalities. The present invention relates to a disrupted organic anion transporting polypeptide-related protein-4 (OATPRP4) It has been shown that a gene and / or one or more product proteins of that gene are involved in TS phenotypes and related abnormalities. In addition, contacting a transgenic animal having a disrupted homologue of the human OATPRP-4 gene and / or one or more disrupted product proteins of that gene with a compound or small molecule, TS and / or associated abnormalities Reducing, reversing or adjusting signs and / or symptoms related to TS and / or related abnormalities, including the process of measuring and / or observing the reduction, recovery or adjustment of any signs and / or symptoms of Provide research models for screening compounds and / or small molecules. |