http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006504426-A
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
filingDate | 2003-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2006-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2006504426-A |
titleOfInvention | Qualitative difference screening for detection of RNA splice sites |
abstract | The present invention identifies and / or clones nucleic acid regions that represent qualitative differences associated with alternative splicing and / or insertions, deletions located in RNA transcribed genomic regions between two physiological situations. Method for hybridization of RNA derived from a test situation and cDNA derived from a reference situation and / or vice versa, or a double-stranded hybrid between a cDNA derived from a test situation and a cDNA derived from a reference situation And a method for identifying and / or cloning nucleic acids that exhibit qualitative differences. The present invention relates to a composition or bank of nucleic acids that represents a qualitative difference between the two physiological situations obtainable by the above method, and to identify a gene or molecule of interest or further eg in a method of pharmacogenomics It relates to their use as probes and to the profiling of molecules against the therapeutic and / or toxic effects of the molecules. The invention further relates to the use of RNA splicing dysregulation as a marker for predicting the toxicity and / or efficacy of molecules and as a marker in pharmacogenomics. |
priorityDate | 2002-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 687.