| abstract |
PROBLEM TO BE SOLVED: To provide a novel compound as an analgesic agent for suppressing, alleviating or treating pain illness or inflammatory disease, and a pharmaceutical composition comprising the same. The present invention relates to novel N-hydroxythiourea, urea and amide compounds, and pharmaceutical compositions comprising them as potent vanilloid receptor antagonists. The compounds of the invention are pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, joint pain, neuropathy, neuropathy, diabetic nephropathy, neurodegeneration, neurodermatosis, seizures, bladder hypersensitivity , From irritable bowel syndrome, respiratory disease such as bronchial asthma / chronic obstructive pulmonary disease, skin / eye / mucosal inflammation, fever, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease, and emergency urinary incontinence It may be useful as an analgesic that suppresses, relieves or treats painful or inflammatory diseases. |