| abstract |
The present invention is a compound of formula (I) [Chemical 1] (Wherein R1 to R5 and Ar have the meanings set forth in the claims) To a 3-guanidinocarbonyl-1-heteroaryl-indole derivative represented by: The compound of the present invention is suitable as an antiarrhythmic agent having a cardioprotective component for the prevention and treatment of infarction and the treatment of angina, for example. They further prophylactically inhibit pathophysiological effects associated with the occurrence of ischemia-induced damage, particularly in the induction of ischemic cardiac arrhythmias and heart failure. |