| abstract |
The present invention relates to the formula (I): [R 1 is a hydrogen atom or a halogen atom; R 2 is a hydrogen atom, etc .; R 3 is a C 1-10 alkyl group; the alkyl group in R 3 consists of a substituent α Substituted with at least one substituent selected from the group; the substituent α is selected from the group consisting of an aryl group, a hydroxy group, an oxo group, etc .; the aryl group is C 6-10 ; the aryl group is unsubstituted Or substituted with at least one C 1-6 alkyl group; the heterocyclic ring group and the heterocyclic moiety in the heterocyclic carbonyl group have 1 to 4 heteroatoms selected from the group consisting of a nitrogen atom and the like. Or a pharmaceutically acceptable amide of the compound, or a pharmaceutically acceptable ester of the compound, and a pharmaceutically acceptable thereof. Provide salt. These compounds have 5-HT 4 receptor binding activity and are therefore useful in the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome, etc. in mammals, especially humans . The present invention also provides a pharmaceutical composition comprising the compound. |