| abstract |
Compounds of formula (I) have an unexpectedly high affinity for Alk5 and / or Alk4 and are useful as antagonists to prevent and / or treat a number of diseases (including fibrotic disorders) It can be. In one embodiment, the invention features a compound of formula (I). The compounds of formula (I) are unexpectedly potent antagonists of Alk5 and / or Alk4, which are TGFβ lineage type I receptors. Therefore, compounds of formula (I) may be used in diseases such as fibrosis (eg, renal fibrosis, pulmonary fibrosis and liver fibrosis), advanced cancer, or other where a reduction in signaling activity of the TGFβ lineage is desirable. It can be used in the prevention and / or treatment of disease. |