| abstract |
Disclosed are isolated human monoclonal antibodies and antigen binding portions thereof that specifically bind to dendritic cells. Further disclosed are bispecifics, immunotoxins and antigen conjugates comprising said antibody or antibody portion. This human antibody can be produced in non-human transgenic animals such as transgenic mice capable of producing human monoclonal antibodies of multiple isotypes by causing V-D-J recombination and isotype switching. Furthermore, pharmaceutical compositions comprising the present human antibodies, non-human transgenic animals and hybridomas producing the present human antibodies, and therapeutic and diagnostic methods utilizing the present human antibodies are also disclosed. |