Predicate |
Object |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
filingDate |
2003-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2006-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2006500933-A |
titleOfInvention |
Methods and compositions for modifying pre-mRNA splicing |
abstract |
The present invention includes a step of contacting a pre-mRNA and / or an element of a splicing mechanism with a small molecule compound identified by the methods described herein to suppress a splicing event of the pre-mRNA molecule. A method for suppressing splicing events is provided. Splicing in the pre-mRNA molecule further comprising contacting the pre-mRNA and / or elements of the splicing machinery with a small molecule compound identified by the methods described herein to induce a pre-mRNA molecule splicing event. A method for inducing an event is provided. In addition, administering to the patient a therapeutically effective amount of a compound identified by the methods described herein to inhibit alternative splicing or abnormal splicing events in the pre-mRNA molecule, thereby treating the patient Provided herein is a method of treating a patient having a disorder associated with an alternative or abnormal splicing event of a pre-mRNA molecule. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11371077-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7089502-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019523013-A |
priorityDate |
2002-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |