abstract |
The present invention relates to the chelating agent 1,2-bis (2aminophenoxy) ethane-N, N, N ′, N′-tetraacetic acid (BAPTA) for inhibiting the proteolytic activity of certain metalloproteinases and calpains. To the use of a lipophilic diester. The invention further relates to a disease associated with MMP and calpain in a mammal, comprising administering to the mammal in need thereof a pharmaceutical composition comprising a therapeutically effective amount of the lipophilic diester of the chelating agent BAPTA. The present invention relates to a method for preventing, treating or managing a disorder. |