| abstract |
MEK inhibitor, N-[(R) -2,3-dihydroxy-propoxy] -3,4-difluoro-2- (2-fluoro) useful for treating diseases mediated by MEK activity in mammals Providing a process for producing -4-iodo-phenylamino) -benzamide. SOLUTION: [(4S) -2,2-dimethyl-1,3-dioxolan-4-yl] methanol is used as a raw material, methanesulfonate, (R) -2,2-dimethyl-1,3, -Dioxolan-4-ylmethoxy) -isoindole-1,3-dione, a hydroxyamine derivative, a benzamide derivative is formed and deprotonated. EFFECTS A safe, effective and economical manufacturing process is possible when implemented on a commercial scale. [Selection figure] None |