| abstract |
A novel, biologically active, recombinantly produced BPI (rBPI) protein, and protein fragments that inhibit the formation of dimers and cysteine adducts, resulting in a very useful product for pharmaceutical use Novel DNA sequences encoding products, rBPI products and analogs, plasmid vectors containing the DNA, host cells stably transformed or transformed with the plasmid, recombinant preparations, stable pharmaceutical compositions, and To provide a method of treatment. The present invention relates to a DNA encoding a biologically active fragment of a protein with improved bactericidal / permeability having a leucine residue at position 193 as the carboxy terminal residue. [Selection figure] None |