| abstract |
PROBLEM TO BE SOLVED: To provide a genetically modified animal having a mutation in the SDHC gene that makes it possible to examine a disease caused by mitochondrial-derived reactive oxygen species (ROS) in mammals. A mutated SDHC gene derived from a mammal is introduced, overproduces reactive oxygen species (ROS), shows a decrease in body weight after maturity, and has abnormalities in vision, muscle, and emotional behavior. A genetically modified non-human mammal or a part thereof, characterized in that [Selection figure] None |