| abstract |
PROBLEM TO BE SOLVED: To provide an antibody that reacts with an antigen of a mammal and has low immunogenicity. An antibody comprising a human-derived constant region, and a variable region comprising a chicken-derived complementarity determining region and a human-derived framework structure region is a phylogenetically distant chicken. Since the complementarity-determining region is derived, it has a broad antigen recognition activity against human and non-human mammalian antigens and has low immunogenicity against humans. Therefore, the antibody of the present invention can be used very suitably as a pharmaceutical product. [Selection figure] None |