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publicationDate 2006-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2006223162-A
titleOfInvention Method for isolating and identifying kidney macladensa cells, method for establishing immortal kidney macladensa cells, cell lines thereof, and transformed animals
abstract [PROBLEMS] In basic research on the system abnormality that produces and releases a factor controlling glomerular filtration rate regulation in the tubular glomerular feedback mechanism important for body fluid volume regulation, and in the development of therapeutic agents for improving pathological conditions such as hypertension and heart failure. Providing useful immortal cell lines. A vector containing an nNOS (neural NO synthase) promoter and a reporter gene is introduced into a kidney cell obtained from a transformed animal into which an SV40LT antigen gene has been introduced to isolate an immortalized kidney McLadensa cell. [Selection figure] None
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