| abstract |
PROBLEM TO BE SOLVED: To prevent and treat various allergic diseases, inflammation and immune diseases by having an action of selectively inhibiting PDE7, thereby increasing intracellular cAMP level and further inhibiting T cell activation. Provision of compounds that are useful for The following formula (IA) or (IB): [Chemical 1] In particular, in the formula, R 1 is a cyclohexyl group, R 2 is a methyl group, and R 3 is a hydrogen atom, a nitro group, a cyano group, a halogen atom, a group: —NR 5 R 6 , —C (═O) R 7 , —SO 2 R 7 , —OR 8 , —NR 8 COR 7 , —NR 8 SO 2 R 7 , heteroaryl group, optionally substituted C 1 An imidazo having 6 alkyl groups, an optionally substituted C 1-6 alkenyl group, or an optionally substituted saturated or unsaturated heterocycloalkyl group, A is CR 4 , and B is CH Triazinone derivative. [Selection figure] None |