| abstract |
PROBLEM TO BE SOLVED: To provide a TNF-α production inhibitor useful as a therapeutic agent for autoimmune diseases such as rheumatoid arthritis. A novel compound having a structure represented by the general formula [1] or a salt thereof has excellent TNF-α production inhibitory activity. In the formula, A represents — (NR 4 ) —, — (CR 5 R 6 ) — or —O—, B represents an alkylene or alkenylene group, and R 1 , R 2 , R 4 , R 5 and R 6 represent hydrogen. An atom, an alkyl group, an alkenyl group, an adantylalkyl group, etc., R 3 represents an aryl group or an unsaturated heterocyclic ring, and X represents an oxygen atom or a sulfur atom, respectively. [Chemical 1] [Selection figure] None |