| abstract |
For further vascular target therapy, additional targets that enable specific tumor vascular destruction in vivo are identified to increase the number of targeting options, and further to one component for tumor vasculature destruction Providing drug preparation. Aminophospholipids (eg, phosphatidylserine and phosphatidylethanolamine) are stable and specific markers accessible on the luminal surface of tumor blood vessels, and administration of anti-aminophospholipid antibody alone is a thrombus in vivo. A surprising discovery is disclosed that is sufficient to induce tumor necrosis and tumor regression. Accordingly, the present invention provides methods and compositions based on anti-aminophospholipid antibodies for use in the specific destruction of tumor vessels and in the treatment of solid tumors. [Selection figure] None |