abstract |
PROBLEM TO BE SOLVED: To provide a non-primate mammalian cell that responds to an immunogen and produces a human antibody or an analog thereof, a production method thereof, and a vector and a cell used for the production. Inactivation vectors are used to inactivate endogenous immunoglobulin loci of non-primate mammals by homologous recombination events, and human immunoglobulin genes are introduced into the genome of the non-primate mammals. This results in a transgenic non-primate mammal lacking the ability to produce endogenous immunoglobulin genes and having the ability to produce human immunoglobulins. [Selection figure] None |