| abstract |
To provide a model animal useful for elucidating the involvement of calpain in a neuropathological state in vivo and use thereof. A non-human animal obtained by modifying a gene encoding calpastatin, its offspring animal, a neurodegenerative disease model animal obtained by crossing the non-human animal with another disease model of the same species, and the non-human animal A method for screening a substance that ameliorates a neurodegenerative disease, comprising using the animal or tissue or cells obtained from the above. [Selection figure] None |