| abstract |
Provided is a pharmaceutical composition comprising IFN-β that is useful in immunotherapy and anti-cancer, anti-tumor, and anti-viral therapies. An IFN-β mutein comprising: Val (V) at position 101 of wild-type IFN-β, numbered according to wild-type IFN-β, is replaced with phe (F), tyr (Y), trp (W), or his (H); An IFN-β mutein, wherein the mutein exhibits antiviral activity, which is at least partially neutralized with an antibody against wild type IFN-β. [Selection figure] None |