http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006162623-A

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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86
filingDate 2005-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_335684429d1ecbf41e8ebf2eb94a7f2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20c80ef436dad8952fce9d4eda900afb
publicationDate 2006-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2006162623-A
titleOfInvention A method for automatically measuring endogenous thrombin activity.
abstract The present invention relates to a method for automatically measuring endogenous thrombin activity in a blood or plasma specimen. A) The linear region of the saturated phase of the total reaction rate is measured within a given test-specific time frame, and then b) The binding constant C of thrombin to α 2 -macroglobulin was measured repeatedly using the gradient A of the total reaction rate in the linear region of the saturation phase, where the gradient corresponds to the reaction rate gradient of α 2 MT. And then c) Determine the value of α 2 MT reaction rate and subtract from the corresponding value of total reaction rate, and then d) Measure the raw ETP value by averaging the reaction rate values of free thrombin measured over a linear region of the total reaction rate of the saturated phase. Measurement of the intrinsic thrombin activity (ETP) of a clotted blood or plasma specimen using the turnover rate of the thrombin substrate to be measured as a function of time. [Selection] Figure 1
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