abstract |
Additional neurotrophic factors are provided for diagnosing and treating disorders of the nervous system. (A) a nucleotide sequence comprising a specific sequence; (b) a neublastin polypeptide comprising at least 90% homology to AA 1 -AA 105 comprising a specific sequence or a polypeptide derived therefrom A nucleic acid sequence comprising an open reading frame that encodes the peptide upon expression; (c) a nucleic acid that specifically hybridizes to a nucleic acid comprising a nucleotide sequence consisting of a specific sequence under high stringency solution hybridization conditions, or a complementary strand thereof; and (D) an isolated neublastin nucleic acid comprising a sequence selected from the group consisting of a nucleic acid that is at least 70% homologous to a polynucleotide sequence present as a specific sequence. [Selection figure] None |