| abstract |
To provide a solid agent of isosorbide. An isosorbide preparation comprising a granular pharmaceutical composition containing a crystalline isosorbide having a water content of 0.5% or less and a lubricant and packaged with a packaging material containing aluminum that does not transmit moisture. . [Effects] A pharmaceutical composition containing highly hygroscopic and easily solidified crystalline isosorbide can be made stable and easy to take. |