| abstract |
The present invention relates to the stabilization of pharmaceutically active ingredients sensitive to oxidation, in particular 40-O- (2-hydroxy) ethyl-rapamycin, in particular 40-O- (2-hydroxy) ethyl obtained in crystalline form. -Concerning rapamycin. The present invention discloses a method for producing and stabilizing a crystalline form of 40-O- (2-hydroxy) ethyl-rapamycin, which is achieved by adding an antioxidant. Further provided are pharmaceutical compositions comprising 40-O- (2-hydroxy) ethyl-rapamycin. [Selection figure] None |