| abstract |
PROBLEM TO BE SOLVED: To provide a biaryl derivative having an action of inhibiting collagen synthesis and useful as a therapeutic agent for fibrosis. SOLUTION: General formula (I) [Wherein, R 1 represents a group represented by the formula RL-, a di- (C 1 -C 6 alkyl) amino group, a di- (C 1 -C 6 alkyl) aminosulfonyl group, a hydroxyaminocarbonyl group. And a C 6 -C 10 aryl group substituted with 1 to 3 groups independently selected from the group consisting of halogen atoms; and R is a C 1 -C 6 alkyl group and the like; L is a sulfonyl group, Biaryl derivatives having an aminosulfonyl group, a sulfonylamino group, etc .; R 2 is a hydrogen atom, etc .; A is a group represented by a specific chemical structural formula] or a pharmacologically acceptable salt thereof. [Selection figure] None |