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publicationDate 2006-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2006096757-A
titleOfInvention Sustained release ranolazine formulation
abstract [Problem] To provide a sustained-release ranolazine preparation for oral administration. Ranolazine and a partially neutralized pH-dependent binder that forms a film that is almost insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. Formulation containing the complete mixture. The formulation is suitable for twice daily ranolazine administration and is useful for adjusting the dissolution rate of ranolazine and maintaining plasma human ranolazine levels of 550 to 7500 ng base / mL. [Selection figure] None
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