| abstract |
PROBLEM TO BE SOLVED: To find a compound having a simpler structure than yohimbine which is a pentacyclic condensed heterocyclic compound and having an action similar to that of yohimbine. SOLUTION: Formula (I): [Chemical 1] (Wherein R 1 represents hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an aromatic group, an aralkyl group, an acyl group, an arylsulfonyl group, an alkylsulfonyl group, or a hydroxyl group; R 2 represents a hydrocarbon group; R 3 , R 4 , R 5 , R 6 and R 7 are the same or different and are hydrogen, halogen, alkyl group or alkoxy group; R 8 is hydrogen or acyl group; n is an integer of 1 to 6; a and b are Same or different 1 or 0) Or a pharmaceutical composition or food composition for blocking α 2 receptor, comprising a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof: [Selection figure] None |