| abstract |
PROBLEM TO BE SOLVED: To provide a simple and efficient production method of bicyclic pyrimidine derivatives and synthetic intermediates useful for the treatment and / or prevention of various diseases involving T cells such as allergic diseases and autoimmune diseases. To provide. [Solution] Embedded image Wherein m and n are the same or different and are an integer of 1 to 3 and m + n is an integer of 4 or less, R 1 is a substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, -NR 2 R 3 , -OR 4 etc., X represents halogen etc.) For example, after treating the amine represented by the general formula (II) with a base, the amine is reacted with the compound represented by the general formula (III) or the compound represented by the general formula (IV) to form the general formula ( V) is obtained, and the compound represented by the general formula (V) is reacted with carbon dioxide in the presence of an organic base. A method for producing a bicyclic pyrimidine derivative is provided. [Selection figure] None |