| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67f2bb9a79bd8433343ae221f81551cf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-54 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J3-00 |
| filingDate |
2004-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6e8748317e0aa7f4abaeba4d7293b32 |
| publicationDate |
2006-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2006063052-A |
| titleOfInvention |
Liposome-containing ultrasonic contrast agent and method for producing the same |
| abstract |
PROBLEM TO BE SOLVED: To provide a highly safe ultrasonic contrast agent that achieves efficient bubble delivery and good targeting by stabilizing liposomes and maintaining the retention of encapsulated gas. SOLUTION: The lipid membrane of a liposome has at least one compound selected from a cationic lipid and a sterol together with a phospholipid, a biocompatible gas in the lipid membrane, or the microbubbles in the aqueous phase or the A contrast agent for ultrasonic examination, comprising a liposome encapsulating a precursor. The liposome is prepared easily and efficiently by mixing the lipid membrane component constituting the lipid membrane and carbon dioxide in a supercritical or subcritical state in the presence of at least one compound having a hydroxyl group. can do. Since the ultrasonic contrast agent containing this does not contain toxic organic solvents, such as a chlorinated solvent, it is highly safe. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9446156-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015044805-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012098937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104337766-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5904555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104103430-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010502671-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113573803-A |
| priorityDate |
2004-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |