| abstract |
PROBLEM TO BE SOLVED: To provide a histone deacetylase (HDAC) inhibitor or the like containing a mercaptoacetophenone derivative or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically, it is an object of the present invention to provide an HDAC inhibitor useful for the prevention and / or treatment of cancer, tumors, neurodegenerative diseases and the like. SOLUTION: Formula (I) [Chemical 17] [Wherein, R 1 represents a hydrogen atom, substituted or unsubstituted lower acyl, CONHCH (R 3 ) CO 2 R 4 (wherein R 3 represents a hydrogen atom or substituted or unsubstituted lower alkyl, R 4 represents Represents a hydrogen atom or lower alkyl), etc. R 2 represents a hydrogen atom or a substituted or unsubstituted lower alkyl, Ar represents a substituted or unsubstituted aryl.] An HDAC inhibitor containing a mercaptoacetophenone derivative represented by the above formula or a pharmaceutically acceptable salt thereof as an active ingredient is provided. [Selection figure] None |