| abstract |
PROBLEM TO BE SOLVED: To use an external preparation or injection containing a highly absorbable nucleic acid without using a viral carrier, which has the effect of enabling percutaneous and mucosal absorption of a nucleic acid that could not be sufficiently achieved until now. Is to provide. SOLUTION: A nucleic acid is made of a monovalent to trivalent basic salt and a complex of a divalent or trivalent metal salt or a cationic polymer with a hydrophilic polymer having an ionic functional group. Nanoparticles coated by non-covalent bonding, a method for producing the same, and a skin or mucosa-applied external preparation and injection containing these nanoparticles. [Selection] Figure 1 |