http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006006311-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9019c0ce5cb7b82c85e121f6cac86dce |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-761 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| filingDate | 2004-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91d417c521c14ff0311f24f0f6560645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a164dcc804e9da478b1b48c89d87e213 |
| publicationDate | 2006-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2006006311-A |
| titleOfInvention | Male infertility model animal showing sperm dysplasia |
| abstract | PROBLEM TO BE SOLVED: To provide a model animal capable of reproducing male infertility caused by dominant spermatogenic dysplasia, which has been difficult to maintain and pass until now, and a method for maintaining and substituting such male infertility model animal. To provide a screening method for preventive and therapeutic agents for male infertility using male infertility model animals, a screening method for causative agents of male infertility, and a diagnostic method for male infertility. [MEANS FOR SOLVING PROBLEMS] A gene mutation in which all or part of an endogenous gene encoding a coat actin is inactivated by a gene mutation such as disruption, deletion or substitution, and the function of expressing a coat actin is reduced. A non-human animal such as a mouse in one allele is a male infertility model animal. For example, in a male infertility model mouse, an abnormality occurred in the actin fiber layer contained in the special junction device (ES) in Sertoli cells, and abnormal morphologies of the elongated sperm cells and detachment from the seminiferous epithelium occurred. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114324674-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114557322-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114208776-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114208776-B |
| priorityDate | 2004-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 624.