| abstract |
The present invention relates to the fields of molecular biology, virology, immunology and medicine. The present invention provides compositions comprising regularly repetitive antigens or antigenic determinant arrays, and in particular Aβ1-6 peptide-VLP compositions. More specifically, the present invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The present invention also provides a method for making each of the conjugates and the ordered repeatable array. The composition of the present invention is useful in the manufacture of a vaccine for treating Alzheimer's disease, and as a therapeutic vaccine for preventing or treating Alzheimer's disease and effectively inducing an immune response, particularly an antibody response. Furthermore, the compositions of the invention are particularly useful for effectively inducing a self-specific immune response within the indicated context. |