abstract |
The present invention relates to novel triazoles that are inhibitors of phosphorylation of smad2 or smad3 by the transforming growth factor (“TGF”)-β signaling pathway, particularly the TGF-β type I or activin-like kinase (“ALK”)-5 receptor. Derivatives, their preparation and medicine, in particular their use in the treatment and prevention of disease states mediated by this route. |